HEMOPHILIA A SUBJECTS WITH AN INTRON-22 GENE INVERSION MUTATION SHOW CD4+ T-EFFECTOR RESPONSES TO MULTIPLE EPITOPES IN FVIII

Hemophilia A subjects with an intron-22 gene inversion mutation show CD4+ T-effector responses to multiple epitopes in FVIII

BackgroundAlmost half of severe hemophilia A (HA) is caused by an intron 22 inversion mutation (Int22Inv), which disrupts the 26-exon F8 gene.Inverted F8 mRNA exons 1-22 are transcribed, while F8B mRNA, containing F8 exons 23-26, is transcribed from a promoter within intron 22.Neither FVIII activity nor FVIII antigen (cross-reacting material, CRM)

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Reproducing the Gender Order in the Wake of Disasters. Revisiting a Case Study on a Mudslide Disaster in Austria

While disasters are considered a rupture of the established gender order, they rarely result bushranger awning in its profound change.This paper contributes to a proper understanding of its perpetuation.It suggests to take a disaster as a framework for action that is symbolically shaped by gender expectations.Within this framework, the gender order

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Isolation, fractionation and identification of chemical constituents from the leaves crude extracts of Mentha piperita L grown in Sultanate of Oman

Objective: To analyze and identify the chemical compositions of different organic plants crude extracts of Mentha piperita (M.piperita) grown in read more Sultanate of Oman by gas chromatography-mass spectrometry (GC-MS).Methods: The powder sample was extracted with methanol by using Soxhlet extractor.Methanol crude extracts of M.piperita and its d

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